| Buffalo Sabres (12-8-1, 25pts) | Game #22 | Columbus Blue Jackets (5-13-3 13pts) |
 | vs. | |
| Date: | November 25, 2011 | Location: | Columbus, OH |
| Time: | 7:00 p.m. ET | Arena: | Nationwide Center |
| TV: | MSG | SBN Affiliate/ Blog | The Cannon |
| Radio: | WGR (550AM) | Season Series | 1-0 |
| Category | Buffalo Sabres | Columbus Blue Jackets |
| Goals For | 59 (2.81) | 48 (2.29) |
| Goals Against | 54 (2.57) | 69 (3.29) |
| Shots For | 654 (31.1) | 660 (31.4) |
| Shots Against | 655 (31.2) | 596 (28.4) |
| Power Play | 16/78 - 20.5% (7) | 13/94 - 13.8% (24) |
| Penalty Kill | 68/77 - 88.3% (4) | 53/72 - 73.5% (30) |