| Buffalo Sabres (12-8-0, 24pts) | Game #21 | Boston Bruins (12-7-0 24pts) |
 | vs. | |
| Date: | November 23, 2011 | Location: | Buffalo, NY |
| Time: | 7:00 p.m. ET | Arena: | First Niagara Center |
| TV: | MSG | SBN Affiliate/ Blog | Stanley Cup of Chowder |
| Radio: | WGR (550AM) | Season Series | 0-1 |
| Category | Buffalo Sabres | Boston Bruins |
| Goals For | 56 (2.80) | 63 (3.32) |
| Goals Against | 51 (2.55) | 39 (2.05) |
| Shots For | 620 (31.0) | 607 (31.9) |
| Shots Against | 616 (30.8) | 544 (28.6) |
| Power Play | 14/74 - 18.9% (9) | 11/67 - 16.4% (18) |
| Penalty Kill | 65/72 - 90.3% (2) | 64/74 - 86.5% (8) |