| Buffalo Sabres (21-21-5, 47pts) | Game #48 | New York Islanders (15-24-7, 37pts) |
 | vs. |
|
| Date: | January 23, 2011 | Location: | Uniondale, NY |
| Time: | 3:00 p.m. ET | Arena: | Nassau Memorial Veterans Coliseum |
| TV: | MSG | SBN Affiliate/ Blog | Lighthouse Hockey |
| Radio: | WGR (550AM) | Season Series | 0-2-0 |
| Category | Buffalo Sabres | New York Islanders |
| Goals For | 125 (2.66) | 113 (2.46) |
| Goals Against | 139 (2.96) | 148 (3.22) |
| Shots For | 1585 (33.7) | 1305 (28.4) |
| Shots Against | 1429 (30.4) | 1511 (32.8) |
| Power Play | 33/179 - 18.4% (12) | 32/180 - 17.8% (17) |
| Penalty Kill | 149/182 - 81.9% (17) | 145/180 - 82.2% (14) |