| Buffalo Sabres (9-10-3, 17pts) | Game #22 | Tampa Bay Lightning (10-7-2, 22pts) |
 | vs. |  |
| Date: | November 20, 2010 | Location: | Buffalo, NY |
| Time: | 7:00 p.m. ET | Arena: | HSBC Arena |
| TV: | MSG | SBN Affiliate/ Blog | Raw Charge |
| Radio: | WGR (550AM) | Season Series | 0-0-0 |
| Final Score | |||
| Category | Buffalo Sabres | Tampa Bay Lightning |
| Goals For | 55 (2.62) | 60 (3.16) |
| Goals Against | 66 (3.14) | 63 (3.32) |
| Shots For | 694 (33.0) | 629 (33.1) |
| Shots Against | 614 (29.2) | 530 (27.9) |
| Power Play | 11/84 - 13.1% (26) | 22/87 - 25.3% (4) |
| Penalty Kill | 63/80 - 78.8% (23) | 71/80 - 88.8% (3) |
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